Secondary Structure of Huntingtin Amino-Terminal Region
نویسندگان
چکیده
منابع مشابه
Autophagy regulates the processing of amino terminal huntingtin fragments.
The N-terminus of mutant huntingtin (htt) has a polyglutamine expansion and forms neuronal aggregates in the brain of Huntington's disease (HD) patients. Htt expression in vitro activates autophagy, but it is unclear whether autophagic/lysosomal pathways process htt, especially N-terminal htt fragments. We explored the role of autophagy in htt processing in three cell lines, clonal striatal cel...
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From the Institutes ofHematology* and Internal Medicine,t University ofPerugia, Perugia, Italy; the Institute of Hematology,* University ofBologna, Bologna, Italy; the Department ofPathology,5 Columbia University, New York, New York; the Department ofPathology,11 Niguarda Hospital, Milan, Italy; the Institute of Pathology,9 University La Sapienza, Rome, Italy; the Institute of Pathology,* Free ...
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ژورنال
عنوان ژورنال: Structure
سال: 2009
ISSN: 0969-2126
DOI: 10.1016/j.str.2009.08.002